The study of low penetrance gene variants in a complex genetic disorder such as stroke does not pose the same risks and benefits as a study of highly penetrant mutations.1 Because of the nature of their disease, however, stroke patients may not understand the information given when they are asked for consent to participate in research and are potentially vulnerable subjects. In a systematic review of publications on ischaemic stroke genetics, we assessed the way in which informed consent and ethics (...) committee approval are reported.MethodsWe searched the MEDLINE database for stroke genetics studies published in English between January 2000 and January 2002, using the medical subject heading term “cerebrovascular disorders, genetics of” plus the text words “ischaemic” and “stroke.”2 We included only original clinical trials and observational studies of human genetic risk factors for ischaemic stroke.Both authors independently reviewed every article. We used standardised forms to record whether an explicit statement described informed consent and institutional review board procedures. We also recorded whether …. (shrink)

The relevance of nonlinear dynamics to calcium metabolism led us to reevaluate the role of Ca-regulating hormones in Ca homeostasis. We suggest that, firstly, the main Ca metabolic functions in rat-bone and gut - are organized as dynamic entities able to generate various temporal expressions, including self-oscillating patterns and, secondly, Ca homeostasis results from interaction between both metabolic and hormonal oscillators. Following this schema, a major role for the hormonal system, with its circadian pattern, could be to act directly on (...) metabolic functions or indirectly through feeding behaviour, in order to optimize, coordinate and synchronize the Ca fluxes at ECF level. (shrink)

Roman Catholic moral theology follows a centuries-old tradition of moral reflection. Contemporary Roman Catholic moral theory applies these traditional arguments to the realm of medical ethics, including the issues of active euthanasia and physician-assisted suicide. Unavoidable moral limits on licit medical intervention sometimes require that the moral duty to treat, cede to the duty to cease treatment when measures become more harmful than beneficial to the patient. This does not reduce the need for the compassionate use of palliative care in (...) response to suffering. However, it does mean that rather than being excessively committed to maintaining mere biological human life, or actively seeking death, that we learn a sober realism about the limits of human life. Catholic moral analysis examines an act objectively, both in its relation to the agent and as a material event in the world. This allows both the virtuous or vicious intentions of the agent and the effects of the action to be included in its moral evaluation. Thus, Catholic moral analysis is both quasi-deontological and quasi-consequentialist. Objectively, active euthanasia and physician-assisted suicide, as acts of deliberate killing, are seen as repugnant, in that they fail to incarnate a benign inner intention or to form an agent in virtue. Catholic moral theology is extremely skeptical that an act of intending death directly can be consonant with a sincere compassion for the dying, suffering person and views it as a direct negation of the precious gift of human life. (shrink)

The posterior parietal cortex (PPC) is the most likely site where egocentric spatial relationships are represented in the brain. PPC cells receive visual, auditory, somaesthetic, and vestibular sensory inputs; oculomotor, head, limb, and body motor signals; and strong motivational projections from the limbic system. Their discharge increases not only when an animal moves towards a sensory target, but also when it directs its attention to it. PPC lesions have the opposite effect: sensory inattention and neglect. The PPC does not seem (...) to contain a “map” of the location of objects in space but a distributed neural network for transforming one set of sensory vectors into other sensory reference frames or into various motor coordinate systems. Which set of transformation rules is used probably depends on attention, which selectively enhances the synapses needed for making a particular sensory comparison or aiming a particular movement. (shrink)

Is it possible to interfere with individual decision-making while preserving freedom of choice? The purpose of this article is to assess whether ‘libertarian paternalism’, a set of political and ethical principles derived from the observations of behavioural sciences, can form the basis of a viable framework for the ethical analysis of public health interventions. First, the article situates libertarian libertarianism within the broader context of the law and economics movement. The main tenets of the approach are then presented and particular (...) attention is given to its operationalization through the notion of a ‘nudge’. Essentially, a ‘nudge’ consists in an intervention, which aims to suggest one choice over another by gently steering individual choices in welfare-enhancing directions yet without imposing any significant limit on available choices. Finally, the article concludes that, while it fails as an overreaching framework of ethical analysis, libertarian paternalism nonetheless constitutes a valuable addition to the conceptual toolbox of public health ethics. (shrink)

Posidonivs was fortunate to be born in an age when the Romans had begun to recognize their own intellectual limitations, and had turned for guidance to a hitherto despised nation, admitted by themselves to be as much their superior in originality as it was inferior to them in practical matters. He was, moreover, the official exponent of a philosophical system which, destined as it was to exercise for hundreds of years the strongest moral influence over the world, had already taken (...) a firm hold on the more thoughtful minds at Rome. Probably any Greek teacher of ability had, in the time of Cicero, a good chance to make a name; Posidonius, who was a man of considerable intellectual gifts, great learning, and some originality, and who was, moreover, the accredited successor to Zeno and Chrysippus, obtained a reputation which lasted for some centuries. (shrink)

This collection of essays, addresses, and one interview come from the years 1966-73 and cover a wide spectrum of interest, dealing with such general topics as 'The Absence of God in Modern Culture' and 'The Future of Christianity.'.

The idea of creaturely life has, in recent years, emerged as an important and illuminating category of literary and philosophical critique. In this paper I seek to contribute to this contemporary discourse by examining the references to the creaturely found in the writings of T.W. Adorno. Whilst much attention has been paid to Walter Benjamin’s reflections on creatureliness, Adorno, a thinker with whom Benjamin is often associated, has received comparatively little in this regard. I begin to redress this lacuna by (...) developing a reading of key passages of Dialectic of Enlightenment which orients itself towards Adorno’s remarks concerning the ‘inverse theology’ which he sees as grounding both his own, and Benjamin’s, thought. In placing theological core of Adorno’s philosophy in the foreground of my analysis, I argue that the notion of the creature, which I claim signifies a redemptive perspective on human existence, can be read as an important, if somewhat overlooked, concept in the normative framework of the Dialectic of Enlightenment. (shrink)

Nos três problemas preambulares e nas primeiras lições do Commentarium in De anima atribuído a Pedro Hispano, o autor: 1) discute a possibilidade de urna ciência da alma; 2) compara a ciência da alma com as outras ciências naturais; 3) identifica o método da ciência da alma. Daí emerge uma fundamentação da "ciência da alma" como "ciência do homem" e um modelo de organização das ciências, tendencialmente coincidente com a organização do corpus aristotélico, mas com a reivindicação da superioridade da (...) Ciência da alma por razões gnosiológicas. (shrink)